www.00kcd.com_www.00kcd.com-【乃正式注册】:安踏体育升逾2%破顶今年以来暂累涨四成

www.00kcd.com_www.00kcd.com-【乃正式注册】

2019-04-22 00:30:32

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  Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:

  ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."

  ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.

  Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."

  Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.

  FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."

  ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."

  Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."

  FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.

  AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.

  Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."

  AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Incorporatelife,somanybuzzwordsgetthrownaroundsoquicklythatit'shardtokeeptrack.There's"synergy"and"scalable,""bestpractice"and"leverage."Thelistisendless.Andalthoughthephrase"diversityandinclusion"canbelostinthemazeofcorporatejargon,Idon'tthinkdiversityandinclusionisabuzzwordatall.Rather,Ibelievewhatdiversityandinclusionstandsforisessentialtobusinesssuccess.HereishowIdefinethemastheyrelatetoourcurrentworkforce:Makingsureyourworkplaceemploysindividualswithdifferentbackgroundsandperspectives.Makingsureallemployeesfeelvalued,respectedandgivenaccesstotheopportunitiesthathelpthemgrowintheircareersandenablethemtoaddvaluetoourbusiness.Inmanyways,itisabout"bringingourwholeselvestowork."Wewanttomakesureeveryemployeefeelsvalued;thattheyneverhavetohidewhotheyare.Ifirmlybelievethatdiversityandinclusionaren'tsimply"nice"virtuesforacompanytohaveorboxesforustocheck—theycreatesuccessbothinourbottomlineaswellasinfosteringahappy,healthy,andinvestedworkforce.Iseethisinactioneveryday.AstheleaderofMSD'sGlobalDiversityandInclusionorganization,IworkwithMSD'sleadersacrosstheglobetoensurethatdiversityandinclusionarewovenintothefabricofourbusinesstocreateacompetitiveadvantageforourcompany.Beingthenation'ssecondlargestpharmaceuticalcompany(andtheseventhlargestworldwide),weknowthathavingadiversemindsetisnotjustaniceaspiration—it'sanecessity.Ourcurrentworkforceandmarketplacearemorediverseandglobalthanatanypointinourcompany'slengthyhistory.Themostraciallyandethnicallydiversegenerationeverhasenteredtheworkforceandisexpectedtomakeuphalfoftheglobalworkforceby2020.ThisdynamicdemandsaverydifferentMSDhereandabroad—onethatunderstandsandcanhelpaddresstheneedsofanincreasinglydiversebaseofpatients,customers,employeesandsuppliers.Nowhereisthismoreimportantexternallythaninourclinicaltrials.Clinicaltrialsarecriticallyimportantresearchstudiesthattesthowwellnewmedicalapproachesworkinpeople;theyareattheheartoftheprocessforbringingnewmedicinestopatients.Butalargepercentageofclinicaltrials,regardlessofthedisease,arecomposedofwhitemales.TheFDAhasnotedthatwhileAfrican-Americansrepresent12percentofthetotalU.S.population,theymakeuponly5percentofclinicaltrialparticipants.AtMSD,weareinspiredbyasharedmissiontosaveandimprovelives.AlargepartofwhatIdoislookforwaystohelpincreasetheminorityparticipationinourtrials.Inaworldofmanyethnicitiesandcultures,itisimportantthatthesesubjectsreflectourpopulation.ThegoalIsetwhenIcameintothisroleseveralyearsagoremainsthesame:tomakediversityandinclusionnotjustapartofourframework,butingrainedinourDNAinhowourmanagershire,promoteanddeveloptheiremployees.Wearemakingprogress,butIwanttogetustothepointwhereweshapewhathappensnotonlyinthepharmaceuticalindustry–butinallcompanies.Basically,mydreamforMSDistogettotheplacewhereplacingtheweightofvaluingglobaldiversityandinclusionisn'tononeperson'sshoulders,butinthemindsandheartsofeveryone.Ithinkit'sagreatdreamtohave.OtherMSDoutreach:AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."FROMUGANDATOBHUTAN,VIETNAMANDINDIAAWORLDWIDEEFFORTAGAINSTHPV-RELATEDCANCERSMSDcollaborateswithorganizationsandlocalgovernmentsworldwidetohelpfostercommunityaccesstoHPVeducation,preventionanddetectionmethods.ByhelpingtoraiseawarenessoftheconnectionbetweenHPVandcervicalcancer,increasingaccesstocervicalcancerscreeningsandotherpreventionprograms,weaimtoempowercommunitiesworldwidetoreducetheburdenofcertainHPV-relatedcancers.

  Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”

  Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."ForAngelaJablonski,Ph.D.,thefightagainstAlzheimer'sdiseaseisapersonalone."PeopleveryclosetomedevelopeddementiaandAlzheimer'sdisease,anditwasextremelyhardtowatchtheirstruggles–notbeingabletodotheirregularactivitiesorremembernames,memoriesorlovedones,"sherecalls."Whenadiseasetargetsthebrain,ittakesawayapartofouridentityandourmemory--whatmakesusus.AngelasaysthatherpersonalexperienceswithlossanddiseaseslikeAlzheimer’sforcedhertolookinsideherself."Iaskedmyselfwhythesethingswerehappening,andIcouldn’tanswerthatquestion.ButIbelievethoseexperiencesandwitnessingthepainitcausedgavemethepassionandmotivationtotacklechallengingneurologicaldiseases.Myfamily’sstrugglesarewhyIgetupinthemorningandkeepgoing."ChoosingtheMRLPostdoctoralResearchFellowprogramAngelaoriginallycametoMSDaftergraduatingfromtheUniversityofPennsylvaniatoparticipateinour"WiththeMSDpostdoc,Iwasabletoexperiencedrugdiscoveryfirsthand,versustakingaclassorreadingaboutitinabook.IknewthatifIcametoMSD,ifImadeanimportantdiscovery,itwouldbehere,withpeoplewhocanreallyturnanideaintoatherapyoratargetforanewdrugoranewtreatmentforadisease.That'swhyIpickedMSD."Inhertwoyearsworkingintherotation,Angelasaysshewasencouragedtopublishandtraveltopresentherwork."Whileapostdoc,IgottodoresearchthatIwaspushedtopublishandshareonaninternationallevel.IwasabletogotoIrelandtopresentataprestigiousconferenceformyfieldandinteractwithpeoplewhoareconsideredtheworld'sexpertsonneurodegenerativediseases.Iwasproudtosharemyresearchwiththem.MSDgavemetheopportunitytotravel,seetheworldandmeetoutstandingscientistsfrommultiplebackgrounds."TheresearchcontinuesNowwithherpostdoccompleted,AngelahasdecidedtostayonatMSDasaseniorscientist,workingonneurologicaldiseasesinourWestPointlabs."Lookingback,Icouldn'thavemadeabetterdecisionthantocometoMSD.Itwastherightone.I'mgladItooktheopportunitywhenitcame.IlookbackjustattheshorttimeI'vebeenhereandI'malreadyabetterscientist,I'mabetterperson,andI'mabetteremployee."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

  AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”AlthoughRNAisequallyasimportantasDNAinbuildinglife,wehaven'talwaysgivenitequalbilling.RNAhashistoricallybeenthoughtofasamessenger,whosemainjobistocarrygeneticinformationbackandforth(animportantjob,sure,butnotaveryglamorousone.)ButwhatifRNAiswaymorethanacarrierpigeon‘It'sbecominganRNAworld’EnterJohnHowe,aMSDscientistwhoistargetingRNAasameanstopossiblydevelopantibiotics.It'sbecominganRNAworld,henotes.PeopleunderstandnowmoreandmorethatRNAisnotjustapassivemessenger.Itactuallyplaysanactiveroleinregulatingcellfunction.In2015,JohnandteammadebigwavesinthescientificcommunitywhentheypublishedacoverstoryintheleadingscientificjournalNatureregardingabreakthroughtheymadeinidentifyinganewtypeofsyntheticmoleculewithantibacterialproperties.TheyfoundthatbytargetinganRNAstructuralelementinbacteriaitwaspossibletoblockcellgrowthinamannersimilartoantibiotics.Whattheteamhasshownisthepotentialtousesmallmoleculestoimpactanentirelynewclassoftargets.Consideringthatevidencehasshownthatbacteriaareabletoacquireresistancetoantibiotics,findingadifferentwaytocreateantibioticsispromisingnews.Wethinkthere'spotentiallyawholenewfieldofRNAtargetsavailablethatwecanresearchasapotentialwaytotreatbacterialinfections,Johnsays."Ican'twaittogettothelabeachmorning"JohnhashadaprettystoriedcareerwhileatMSD.A22-yearveteranofthecompany,hefirstmadehismarkinHCVresearch.In2014,hewaspickedtoleadaprojecttodiscovernewmoleculeswiththepotentialforactivityagainstdisease-causingbacteria."GoingfromprojecttoprojectisnotunusualatMSD;it'spartofourcareerdevelopment.Theleadershipherehasalwaysbeenverysupportiveandhelpedmetobroadenmyskillsetandopenupnewcareeropportunities.""There'srarelyadaywhenIdon'tlookforwardtogoingtowork.Ican'twaittogetinthelabeachmorningandseeifmyexperimentfromthenightbeforeworked,"Johnsays."MovingaroundtodifferentareasofresearchatMSDhasallowedmetolearnandgrow,whilegivingmetheopportunitytocontributetosomereallyvaluablenewtreatmentsthatultimatelyimprovepeople’slives.That’swhatkeepsthingsfreshandexciting,andmakesgoingtoworkeachdaysosatisfyingforme."

  Dedicatedtofindingthe'elusive'targets"Iamworkingonatargetthatwestilldon'tunderstandeverythingaboutandIthinkthat'sgoingtobethecaseaswegoforwardwithnewtargetsthey'regoingtobetrickier,”Luiscomments.“Butatthesametime,thatunknownfuelsthepassionoftryingtouncoverandunderstandnewtargets."Manytumorsremaindifficulttotargetbecausetheirbiology(aka:howtheyoperatewithinthecomplexhumansystem),isnotwellunderstood.ThisisthechallengeforLuisandhiscoworkers."Forthetargetsthatstillremainelusive,theamountofworkthatgoesintotryingtounderstandthosetargetshowtheycontributetocancertolerance,howtheycontributetoregulatingtheimmunesystemtokeepitfromfightingthatcancertheamountofworkthatgoesintotryingtounderstandthatbiologytakesyears,"henotes."Ifyouaddupallthepeoplethatworkonaparticularprogram,we'retalkingaboutpotentiallydecadesofworktouncoverasingletarget."FortunatelyforLuis,he'snotworkingalone.“Thebestideasareanamalgamofthoughtsthatcometogethertosolveaparticularquestion.Iworkwithgroupsofpeoplewhoexplorecancerbiologyfromdifferentangles,exposingustonewavenuesofthought.Combiningmultiplescientificapproachesallowsustobemuchmorecreativeinhowwefindanswerstothemanyquestionswehaveinoursearchfornewtargets."MovingtoSouthSanFranciscoLuishasworkedinPaloAltoforsixyearsandisabouttomovetoournewSouthSanFranciscolabs."ThemovetoSanFranciscowillopennewopportunitiesforustoworkwithgreatmindsinmanyscientificfieldsthatareadvancingrapidlyrightnow,includingimmunology,computationalbiology,genetics,tonamejustafew.Itreallywillputusinthecenteroftheaction,"henotes.“Themovewillmakeusmoreaccessibletomanyexpertswhocanhelpusaddressthequestions,'HowdoweunderstandcancerbetterHowcanwebettertargetcertaincancersWhatpatientpopulationswillbenefitthemost'"Foranyexplorationtobesuccessful,teamworkandexpertiseareessential,soLuisandhiscolleaguesoftenseekinputfromoutsideourlabs."Theonlywayforustofacilitatethisbasicresearchandsometimeslookatitinadifferentlightistogooutsideofourimmediateteams,'"henotes."Increasingouraccessibilitytocollaboratorsinindustryandacademia,Ibelievewillimproveourcapacitytoexpandonthesequestionsthatwehaveandhopefullyleadtonewinsights.Wemaybeabletodiscovernewthingsthatwewouldn'thaveotherwisebeenabletodoonourown."AteameffortmakesDreamnightpossibleJohnandhiscolleagueRaymondvanBakelareamongapproximately1,500volunteersfromtheAmsterdamareawhomakeDreamnightpossible.AsmembersofMSD’semergencyresponseteam,RaymondandJohnworkcloselywiththeAmsterdamfiredepartmenttoorganizeMSD’srole.Johntransportsuptosevenchildrenatatimeduringtheprocession.“ThesearechildrenwhomaybehookeduptoIVs,inwheelchairsorhavedevelopmentaldisabilities.Itwouldbeverydifficultfortheirparentstotaketheirkidstothezoo,"henotes.TakingpartinvolunteeringactivitiesColleaguesatourHaarlemsitealsoparticipateinavarietyofothervolunteeropportunitiesthroughouttheyear,suchastakingcareofalocalchildren’sfarmpopulatedwithpeacocks,chickensandsmallfarmanimals.VolunteersalsotakepartineffortsthathelptheelderlyandsupporttheRedCross.Theyevenmanagetrafficforcommunityevents.“Wehavealargenumberofemployeeshere.Whenyoutakepartinteamvolunteeringactivities,youhaveanopportunitytomeetpeopleyoumayneverspeaktoatwork,”saysJohn.“Butafteryou’veteamedupwithacolleaguetorepairaroadsothatgoatscanwalkacrossitortocleanoutachickencoop,whenyouseethatindividualatworkyou’reexcitedtograbacupofcoffeeandhavesomegreatconversations.”Medicationonlyworksifyoutakeit.ThisiswhatmakesStephanieBarrett’sjobsoimportant.StephanieleadsateamatMSDthatworksoninventinglong-actingformulationsofourmedicines.“Theselong-actingformulationsaredevelopedtogivepatientsnewoptionstotaketheirmedicines,”shenotes.“Iaminspiredbythepotentialforlong-actingformulationstotreat—andevenhelpprevent—certaindiseases,”shenotes.“Iwouldfeelanincredibleamountofpridetocontributetoanewoptionforpatients.”‘Wegettoinventeverysingleday’Stephaniehashadmanyrolesinourlabssinceshejoinedthecompanyalmost10yearsago,butshe’sespeciallydrawntohercurrentteam’smissionandhowitworkstowardsMSD’sgoalof.“Ithinkoneofthemostfunpartsofourjobsisreallytoinvent.Wegettoinventeverysingleday,sometimesit'slittlethings,sometimesit'sbigthings,”shesays.“ButIthinkattheendofthedayIrealizethatalloftheselittlethingsthatwe'reinventingworktowardsacommongoalofreallyhavinganimpactonsavingandimprovinglives.”

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